A recent study indicates that patients who come off popular slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who end conventional lifestyle regimens.
Published data in a major health publication shows that while obese individuals frequently drop about a fifth of their total mass while using the jabs, the weight returns at an average rate of 0.8 kg per month upon discontinuation.
"Users purchasing such drugs should be informed of the risk of quick weight regain when the treatment concludes," cautioned researcher Dr. Susan Jebb.
Such speed of regain implies a return to pre-treatment weight within about 18 months.
Weighing Therapies
The study, which reviewed dozens of trials involving thousands of patients, contrasted the results of GLP-1 agonists with older methods.
Researchers note that individuals who shed pounds through lifestyle changes alone usually see a less rapid weight regain—approximately 0.1 kg a month—post-intervention.
Understanding the Fast Regain
Doctors suggest the mechanism of the injections is key to understanding the heightened rebound.
The injections mimic a body's own chemical called glucagon-like peptide-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 levels far above than the body's typical production could lead to the system to produce less of its endogenous hormone, and could reduce sensitivity to its effects," said Dr. Adam Collins, a dietetics expert.
"Discontinuation of this hormone supplement results in appetite is no longer kept in check, making binge eating a significant risk."
A Lifelong Condition?
Medical guidelines suggest the injections for individuals with obesity-related health risks, alongside prescribed diet and exercise modifications.
A number of clinicians contend that, considering the significant potential of relapse, the therapy might need to be ongoing.
This view is supported by pharmaceutical companies, who state that the findings "highlight the long-term nature of excess weight," akin to managing conditions like diabetes.
User Testimonies
Users who have discontinued the medication report a sudden return of hunger.
"I experienced a trigger that goes on and I was suddenly starving," said one woman.
This difficulty is worsened if individuals have not adopted permanent dietary or behavioural changes during treatment.
Significant Use
Recent estimates indicate that millions of adults in the UK have tried these injections in the past year, with demand remaining high.
- Use is greater among women compared to men.
- The middle-aged age group shows the highest usage rates.
- A large proportion access the drugs through private healthcare rather than the NHS.
Ultimately, researchers caution that while these medications are effective agents for weight loss, they are not a standalone solution and long-term success likely depends on ongoing lifestyle management.
